科学研究

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    【J.Nat.Prod.】Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes

    来源: 日期:2024年02月23日 15:44点击:

    Protoilludane-Type and Related Nor-Sesquiterpenes from Phellinus hartigii and Their Anti-Hypertrophic Activities in Rat Cardiomyocytes

    By: Quan Fu, Jing Yuan, Tie-Hua Yang, Jin-Hao Su, Jing-Jing Zhang, Xue-Wen Wu, Hong-Ye Zhang, Wei-Lie Xiao, Chang-Bo Zheng, and Xiao-Li Li

    Journal of Natural Products

    DOI:https://doi.org/10.1021/acs.jnatprod.3c00985

    Published:2024-02-03

    Abstract

    Three nor-sesquiterpenes, phellinharts A-C (1-3), isolated from Phellinus hartigii, exhibited unprecedented protoilludane and cerapicane-type structures. The structures of compounds 1-3 were elucidated via spectroscopic analysis, quantum chemical calculations, and X-ray diffraction. Potential biogenic pathways involving demethylation, ring cleavage, and rearrangement were proposed. Compounds 1-3 displayed potent anti-hypertrophic activities with low cytotoxicity (CC50 > 50 mu M) in rat cardiomyocytes, underscoring their therapeutic potential.



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