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    【Nat. Commun.】Nickel/photoredox Dual Catalyzed Arylalkylation of Nonactivated Alkenes

    来源: 日期:2023年12月04日 10:53点击:

    Nickel/photoredox Dual Catalyzed Arylalkylation of Nonactivated Alkenes

    By: Yuxi Gao, Lijuan Gao, Endiao Zhu, Yunhong Yang, Mi Jie, Jiaqian Zhang, Zhiqiang Pan, Chengfeng Xia

    Nature Communications

    DOI:https://doi.org/10.1038/s41467-023-43748-4

    Published:2023-11-30

    Abstract

    Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp3)-C(sp3) bond and one C(sp3)-C(sp2) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds.

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